Alexei V. TEPIKIN

(Liverpool, UK)

CURRICULUM VITAE

Date of Birth: 3 June 1961.

Nationality: British Present address: Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown street, P.O. Box 147 Liverpool L69 3BX

Employment History: Current position: Professor of Physiology, Department of Cellular and Molecular Physiology, University of Liverpool, UK. (July 2002 – present)

Educational Qualifications: 1988: PhD in Biophysics, A.A. Bogomoletz Institute of Physiology, Kiev (Ukraine). PhD supervisor Professor P.G. Kostyuk. 1984: BSc in Biophysics, Moscow Physical and Technical Institute, Moscow (USSR). Not clinically qualified. Not clinically active.

Publications The publications can be found using PubMed search at: http://www.ncbi.nlm.nih.gov/pubmed?term=Tepikin_A

Selected Publications Okeke E, Parker T, Dingsdale H, Concannon M, Awais M, Voronina S, Molgó J, Begg M, Metcalf D, Knight AE, Sutton R, Haynes L, Tepikin AV. Epithelial-mesenchymal transition, IP3 receptors and ER-PM junctions: translocation of Ca2+ signalling complexes and regulation of migration. Biochem J. 2016 (15), pp. 473(6):757-67.

Chvanov M, Wei H, Jin T, Wen L, Armstrong J, Elliot V, Alston B, Burdyga A, Criddle D, Sutton R, Tepikin A. Novel lipophilic probe for detecting near-membrane ROS responses and its application for studies of pancreatic acinar cells: effects of pyocyanin and L-ornithine. Antioxid Redox Signal. 2015, 22 (6). pp. 451-464.

Voronina S, Collier D, Chvanov M, Middlehurst B , Beckett A, Prior I, Criddle D, Begg M, Mikoshiba K, Sutton R and Tepikin A. The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells. 2015, Biochem J, 465 (3). pp. 405-412.

Burdyga A, Conant A, Haynes L, Zhang J, Jalink K, Sutton R, Neoptolemos J, Costello E, Tepikin A. cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: Effects of PKA and EPAC. Biochim Biophys Acta. 2013 Dec;1833(12):2664-72.

Dingsdale H, Okeke E, Awais M, Haynes LP, Criddle DN, Sutton R and Tepikin AV. Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells. Biochem J. 2013, 451 (part 1): 25-32.

Voronina SG, Barrow SL, Simpson AW, Gerasimenko OV, da Silva Xavier G, Rutter GA, Petersen OH, Tepikin AV. Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells. Gastroenterology, 2010, 138, 1978-1987.

Gyorgy Lur, Lee P. Haynes, Ian A. Prior, Oleg V. Gerasimenko, Stefan Feske, Ole H. Petersen, Robert D. Burgoyne and Alexei V. Tepikin. Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP3 receptors. Current Biology, 2009, 19(19):164853.

Barrow SL, Voronina SG, da Silva Xavier G, Chvanov MA, Longbottom RE, Gerasimenko OV, Petersen OH, Rutter GA and Tepikin AV. ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile. Pflugers Arch (European J Physiol) 2008, 455(6 ):1025-39.

Sherwood MW, Prior IA, Voronina SG, Barrow SL, Woodsmith JD, Gerasimenko OV, Petersen OH and Tepikin AV. Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells. PNAS 2007, 27, 5674-5679.

Chvanow M, Gerasimenko OV, Petersen OH, Tepikin AV. Calcium-dependent release of NO from intracellular S-nitrosothiols. EMBO J. 2006, 25, 3024-3032.

Voronina SG, Gryshchenko OV, Gerasimenko OV, Green AK, Petersen OH, Tepikin AV. Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration. J Biol Chem. 2005, January; 280 (3): 1764-1770.

Voronina S, Barrow S, Gerasimenko O, Petersen O.H., Tepikin A.V.(2004) Effects of secretagogues and bile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating Δψm. J Biol Chem. June 25; 279(26):27327-38.

Ashby MC, Camello-Almaraz C, Gerasimenko OV, Petersen OH, Tepikin AV. (2003). Long distance communication between muscarinic receptors and Ca2+ release channels revealed by carbachol uncaging in cell-attached patch pipette. J.Biol.Chem. 278, N23 (6), 2086020864.

Voronina S, Longbottom R, Sutton R, Petersen O.H., Tepikin A.V. (2002). Bile acids induce calcium signals in mouse pancreatic acinar cells. Implications for bile-induced pancreatic pathology. J. Physiol., 540(1): 49-55.

Lomax R.B, Camello C, Van Coppenolle F, Petersen O.H., Tepikin A.V. (2002). Basal and physiological Ca2+ leak from the endoplasmic reticulum of pancreatic acinar cells: second messenger-activated channel and translocons. J.Biol.Chem., 277 (29), 26479-26485.

Ashby M. C., Craske M, Park M.K., Gerasimenko O.V., Burgoyne R.D. Petersen O.H., Tepikin A.V. (2002). Localised Ca2+ uncaging reveals polarised distribution of Ca2+ -sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves. J.Cell. Biol. 158 (2), 283-292.