Jonathan H. JAGGAR

(Tennessee, USA)

I received a Ph.D. in ion channel physiology from the University of Sheffield, England. Subsequently, I received postdoctoral training in the laboratory of Dr. Mark T. Nelson at the University of Vermont in the USA. During my postdoctoral research, I studied the regulation of calcium sparks and K+ channels in arterial smooth muscle cells. In 2000, I began an independent faculty position in the Department of Physiology at the University of Tennessee Health Science Center (HSC) in Memphis, USA. I am now the Bronstein Endowed Professor of Physiology in the same Department. My research program studies physiological functions and pathological alterations in vascular ion channels. I have studied signaling mechanisms and physiological functions of local and global calcium signals, mitochondria, IP3 receptors, voltagedependent Ca2+ channels, TRP channels, Ca2+-activated Cl- channels, large-conductance Ca2+activated K+ channels, gas transmitters and ion channel trafficking. Research in my laboratory uses a wide variety of molecular, biochemical, cellular, and functional techniques and cardiovascular disease and genetic animal models. My research program is funded by the National Institutes of Health and the American Heart Association.