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Andrew L. MILLER

Andrew L. MILLER

Andrew L. MILLER

(Hong Kong, China)

Prof. Andrew L. Miller received his B.Sc. (Hons) and PhD from the Department of Botany, University of Dundee, Scotland. He then spent 3 years as a Postdoc in the Department of Microbiology at the University of Aberdeen, Scotland, followed by 7 years as a year-round scientist at the MBL, Woods Hole, USA, initially as a Postdoc, and then as an Assistant Scientist. In 1995, he took up a position as an Assistant Professor in the Department of Biology at The Hong Kong University of Science and Technology (HKUST). He is now a Professor in the Division of Life Science, HKUST. His main interest is investigating the role played by Ca2+ in the signal transduction pathways regulating development. He studies Ca2+ signaling mainly through the use of aequorins, a group of Ca2+-sensitive bioluminescent proteins. The luminescence emitted by an aequorin-loaded cell, tissue, organ or intact embryo, reveals changing patterns and levels of free Ca2+. His interests include investigating the role of Ca2+ signaling during basic developmental pattern-forming processes, such as in fertilization, cytokinesis, gastrulation, segmentation, and organogenesis. His work also focuses on identifying the molecular components responsible for generating both local and pan-embryonic Ca2+ signals, as well as identifying Ca2+-sensitive target elements interacting with both types of Ca2+ signal. His current focus is investigating the role of TPC2-mediated Ca2+ release during the establishment of the early spinal cord circuitry and the development of skeletal muscle using zebrafish as an in vivo model system.